You may have some trouble fitting this large game in your window. But that's sure worth it. Protect different maps with nice towers.

A simple tower defence game with StarCraft sprites, nothing too special.

Asteroids tower defence. Build your probes to defend the base from asteroids. Original game with nice towers and upgrades. And also a small funny story attached.

A science-fiction defense game from Packed. Build large turrets to shoot down the enemies in this beautiful game.

This game is just a clear ripoff from Roman Sanine's Tower Defence 1. Protect your castle from being invaded by some members of Kongregate. Doesn't bring anything new besides some nicer colors.

More fuzzy, fur monsters that attack and need to be stopped in a light themed game.