Based on the real life human defense system. Defend against evil bacteria and viruses. It's possible to build a maze like DesktopTD. The game and towers are pretty complex but once you've figure it...

Buy police officers and cars to stop the infamous mafia-boss called Bad Sam. A cops vs. mob tower defense game in the city. Use the mouse to buy, place, upgrade and sell your defense.

A cute looking and extremely well balanced tower defense game that plays on your desktop. Build a maze of towers for one or more lines of creeps.

A towerdefence game from the BBC for their new mini-serie Meta4orce, all in beautiful 3D vector graphics. Non upgradeable towers and a difficult game to finish. Professional made tower defense!

Frontline Tower Defence is all about preventing bugs from reaching the other side. Only classic mode available but thats the most fun anyway. Typical tower-maze game if you know what I mean...

You are commander of defensive forces.You must defend all 12 sectors of village from invaders. You have building materials, 3 types of towers and mad-kamikaze-villagers at your command. Good luck!